Epigenetics of Acute Lymphocytic Leukemia

The role of microRNA in acute/chronic, myeloid/lymphocytic leukemia

MicroRNAs are small, non-coding sequences that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. These molecules control many intracellular physiological and pathological processes.Abnormal expression of these moleculs has been described in different cancers including hematopoietic cancers. According to the type of cancer and the stage, miRNA’s expres...

Acute Lymphocytic Leukemia

By Alvin M. Mauer I T IS TRULY gratifying to review the progress that has been made in the therapy of the acute leukemias since the introduction of aminopterin by Farber and coworkers’ in the late I 940s. This progress can be measured by the increasing proportion of patients who have achieved complete remission, the increasing duration of their survival, and the increasing evidence that for som...

Epigenetics: a New Therapeutic Approach in Chronic Lymphocytic Leukemia

Acute leukemia occurring during chronic lymphocytic leukemia.

By PETER McPHEDiw r AND CLARK W. HEATH, JR. T HE CONCEPT OF “BLAST CRISIS” in chronic leukemia implies a single disease process advancing from chronic to acute phase. How often this happens in chronic lymphocytic leukemia, or whether it happens at all, is uncertain. Unlike chronic granulocytic leukemia, chronic lymphocytic leukemia does not often end in acute leukemia. While it is possible that...

Common Acute Lymphocytic Leukemia Antigen

Common acute lymphocytic leukemia antigen (CALLA' ; CD10) is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) (references 1-8) . It is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL, and is absent from normal PBMC. However, CALLA is not restricted to leukemic cells and is found on a variety of normal tissues (9-14) . ...